Exploration of the network pharmacological mechanism of Wenpi decoction in"treating different diseases with the same method"for chronic renal failure,irritable bowel syndrome and peptic ulcer
XIAO Juan
HUANG Mei
DONGFANG Zihan
LI Zhengfen
YU Xiaoling
LI Jiang
Abstract：Objective To explore the mechanism of action of Wenpi decoction(WPD)in treating chronic renal failure(CRF),irritable bowel syndrome(IBS)and peptic ulcer(PU)based on the traditional Chinese medicine theory of"treating different diseases with the same method".Methods The TCMSP data platform was employed to identify the active ingredients and targets of WPD,GeneCards and other databases were utilized to acquire the targets of CRF,IBS and PU,and Venny software was used to obtain the intersection targets of drugs and diseases.Cytoscape 3.7.2 software was used to map the drug component-target-disease network diagram of WPD for treating CRF,IBS,and PU.STRING platform was used to construct protein-protein interaction(PPI)networks of the common targets of WPD.BioGPS data platform and Cytoscape 3.7.2 software were employed to construct the network diagram of"key targets of WPD-organ tissue".DAVID database was utilized to perform GO functional enrichment analysis and KEGG pathway enrichment analysis.Results A total of 70 intersection targets of WPD were predicted to play the role of treating different diseases with the same method for CRF,IBS and PU.PPI network screened TNF and TP53 as the key targets of WPD for the treatment of CRF,IBS and PU.A total of 323 items were enriched in GO function,mainly involving positive regulation of gene expression and other factors.A total of 119 pathways were enriched in KEGG,including TNF,HIF-1 and other signaling pathways.Active ingredients such as aloe-emodin and kaempferol were in good molecular docking with core targets such as TP53 and TNF.Conclusion WPD treats CRF,IBS and PU through the characteristics of multi-component,multi-target,and multi-pathway,which provides new ideas for the theory of"treating different diseases with the same method"in traditional Chinese medicine,and also provides a bioinformatics basis for the clinical application and mechanism research of WPD.
Keywords：Wenpi decoctionchronic renal failureirritable bowel syndromepeptic ulcertreating different diseases with the same methodnetwork pharmacologymolecular docking
Publication Date：2025-04-30
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：7( 462-468 )