Exploration on mechanisms of Sini powder in treating ulcerative colitis and chronic gastritis with concept of"treating different diseases with the same method"based on network pharmacology and molecular docking
CHAO Yang
WANG Xiaoge
XU Erping
Abstract：Objective To explore the underlying mechanism of Sini powder in treating ulcerative colitis(UC)and chronic gastritis(CG)by using network pharmacology and molecular docking techniques.Methods The main components and corresponding targets of Sini powder were obtained from TCMSP database,the targets of two diseases were obtained by searching DisGeNET,GeneCards and OMIM databases,and the potential targets of UC and CG were obtained by intersection of the two.The"drug-ingredient-target"network model and PPI network diagram were made using STRING database and Cytoscape 3.9.1.GO and KEGG enrichment analyses were performed for intersection targets using DAVID database,and tissue distribution and subcellular distribution information were obtained from BioGPS and GeneCards database.Molecular docking was used to verify the relationship between main components and key targets.Results The four core drugs of Sini powder contained 144 active ingredients and 207 related targets.A total of 1 756 disease targets of UC and 955 disease targets of CG were screened,and 64 potential therapeutic targets were obtained by intersection of the three.The results of GO functional enrichment showed 62 molecular functions,39 cellular components,and 461 biological processes.KEGG analysis showed 142 pathways,among which cancer pathway,IL-17 signaling pathway and TNF signaling pathway might be the main pathways of UC and CG.Molecular docking results showed that the main components quercetin,luteolin,kaempferol,naringenin and nobiletin were well combined with the key targets AKT1,TNF,TP53 and IL6.Conclusion Sini powder may treat UC and CG through its main active ingredients such as quercetin,luteolin,kaempferol,naringenin and nobiletin on core targets such as AKT1,TNF,TP53 and IL6,providing support for better understanding the theory of"treating different diseases with the same method"in traditional Chinese medicine from the perspective of modern medicine.
Keywords：Sini powderulcerative colitischronic gastritistreating different diseases with the same methodnetwork pharmacologymolecular docking
Publication Date：2025-04-30
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：9( 453-461 )