Medication regularity of Chinese patent medicine compounds against chronic hepatitis based on data mining

JI Feng; WU Funing

doi:10.13276/j.issn.2097-1656.2025.04.005

Abstract：Objective To explore the national patent traditional Chinese medicine compound drugs for the treatment of chronic hepatitis,analyze their medication rules and the mechanism of action of core drugs in the treatment of chronic hepatitis,and summarize the treatment principles.Methods The national compound patents for the treatment of chronic hepatitis that met the requirements were collected,prescription information was recorded with Excel software,a database was established,and data analysis was performed with the help of Excel,ancient and modern medical case cloud platform,SPSS Modeler 18.0,and SPSS Statistics 27.0.Results The main syndromes included dampness-heat accumulation syndrome(140,43.61％)and liver depression and spleen deficiency syndrome(63,19.63％).The high-frequency Chinese medicines included Salviae Miltiorrhizae Radix et Rhizoma,Bupleuri Radix,Artemisiae Scopariae Herba,etc.,the medicinal properties were mainly slightly cold,the medicinal taste was mainly bitter,and the meridian tropism was mainly liver meridian.Factor analysis and cluster analysis showed that the combination of new prescription was composed of the addition and subtraction of Four Gentlemen Decoction and Chaihu Shugan powder.Association rule analysis showed that there were 13 highly correlated drug pairs such as"Artemisiae Scopariae Herba-Bupleuri Radix".Conclusion The pathogenesis of chronic hepatitis is deficiency,and treatment of chronic hepatitis focuses on the use of traditional Chinese medicines with functions of soothing liver and regulating spleen,and clearing heat and removing toxin.