Research progress on the relationship between cuproptosis,copper metabolism disorders and neurodegenerative diseases
ZHANG Jimeng
XIE Changcai
LUO Yaowen
FU Yihao
ZHOU Yuefei
YUAN Yunchao
WU Xiuquan
GAO Dakuan
Abstract：Cuproptosis is one of the newly discovered forms of programmed cell death,which differs from traditional forms of cell death such as apoptosis,necrosis and ferroptosis,with its key pathophysiological basis being copper metabolism disorders.The process of copper metabolism includes the uptake,intracellular transport,storage,and excretion of copper ions.Copper metabolism disorders play an important role in the regulation of neuronal function.Furthermore,there is a close relationship between copper metabolism disorders and neurodegenerative diseases,particularly as copper metabolism pathway-related targets have shown promising applications in the diagnosis and treatment of Alzheimer's disease and Parkinson's disease.This paper provides a brief overview of the research progress on cuproptosis and copper metabolism disorders in neurodegenerative diseases,expounding the signaling mechanisms related to cuproptosis and copper metabolism disorders,and offering theoretical support for future drug development and strategy update for new treatment approaches.
Keywords：cuproptosiscopper metabolism disordersneurodegenerative diseasesAlzheimer's diseaseParkinson's disease
Publication Date：2025-03-31
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：7( 401-407 )