Regulatory effect of deep brain stimulation of the nucleus basalis of Meynert on brain networks in Alzheimer's disease
ZHANG Yanyang
XU Junpeng
MAO Zhiqi
YU Xinguang
ZHANG Jianning
Abstract：Objective To explore the regulatory effect of deep brain stimulation(DBS)of the nucleus basalis of Meynert(NBM)on Alzheimer's disease(AD)at the level of brain networks.Methods The preoperative and postoperative multimodal imaging data of 5 patients with severe AD who received low-frequency NBM-DBS treatment from January 2016 to December 2022 were analyzed.Electrode position reconstruction and volume of tissue activated(VTA)were performed to construct brain network connectivity maps of electrically stimulated NBM.Results The postoperative follow-up of 5 cases of NBM-DBS surgery showed no postoperative complications such as infection,electrode displacement and bleeding.A robot-assisted NBM-DBS treatment procedure for AD implantation surgery was determined.The three-dimensional visualization of postoperative spatial structure was realized,which could display the spatial position relationship between electrodes and target nuclei and confirm the precise position of electrode contacts from multiple angles.The VTA of the right electrode contact was(146.89±18.96)mm3,and the VTA of the left electrode contact was(139.67±29.98)mm3.The brain functional networks related to electrical stimulation of NBM mainly involved brain regions located in the default network(21.83％),ventral attention network(15.07％),and subcortical nuclei(12.36％),indicating information exchange between NBM and subcortical nuclei and higher cognitive networks.Conclusion NBM has extensive functional connections to cerebral cortex,amygdala,and other regions,which may serve as the functional basis for NBM-DBS treatment of AD.
Keywords：Alzheimer's diseasedeep brain stimulationnucleus basalis of Meynertbrain network
Publication Date：2025-03-31
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：6( 286-291 )