Preliminary study on the effect of intermittent hypoxia exposure on improving hypoxic endurance in acute high-altitude hypoxia mice
XU Jialing
MAO Guoyun
HU Mingrui
LI Linxia
JI Yaoxuan
ZHI Na
BAI Yanqing
BAI Yungang
WANG Yunying
Abstract：Objective To explore the effects of intermittent hypoxia exposure on the exercise behavior ability of animals under acute hypoxia conditions.Methods Forty 6-week-old male C57BL/6J mice were randomly divided into four groups(n=10):C0 group,CH group,H1 group,and H2 group.After 7 d of preconditioning,the CH,H1 and H2 groups were exposed to acute hypoxia at 5 000 m for 2 h,and anxiety,exercise capacity,and activities of creatine kinase(CK)and lactate dehydrogenase(LDH)were measured.Results Compared with C0 group,acute high-altitude hypoxia caused an increase in anxiety levels(P＜0.05),a decrease in exercise time and distance(P＜0.05),and an increase in CK and LDH activities in CH group(P＜0.05).Compared with CH group without preconditioning,hypoxia preconditioning reduced the anxiety level of mice during acute high-altitude hypoxia,increased the time and distance of exercise,and decreased the activities of CK and LDH(P＜0.05).Conclusion Hypoxia preconditioning has an improvement effect on the formation of anxiety,exercise endurance,and myocardial injury in acute high-altitude hypoxia.
Keywords：hypoxia preconditioningacute hypoxiamyocardialexercise enduranceanxiety
Publication Date：2025-01-27
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)