Research progress in signal transduction pathway and function of CD226 molecule
WEI Kaiqi
HOU Yongli
QIN Qi
LI Juan
CHEN Lihua
TANG Kang
Abstract：CD226 molecule is a member of the immunoglobulin superfamily and is widely expressed on the surface of T cells,natural killer(NK)cells,monocytes,macrophages and other cells.After binding with ligands CD155 and CD112,CD226 extracellular domain activates Src family kinases Fyn and Src on the inner side of cell membrane,and then activates downstream PI3K-AKT and VAV-1-ERK pathways,regulates the differentiation,proliferation,and cytokine secretion of T cells,and enhances cytotoxicity of CD8+T cells and NK cells.Phosphorylated intracellular CD226S329 binds to lymphocyte function-associated antigen-1 and synergistically promotes the formation of immune synapses in T cells and NK cells.Clinical disease-related studies have found that CD226 promotes anti-tumor immune responses,and the presence of CD226+CD8+T cells is a prerequisite for effective immune checkpoint blockade therapy.In addition,CD226 is involved in the occurrence and development of autoimmune diseases such as type I diabetes and systemic lupus erythematosus.A deep understanding of CD226 signal transduction mechanism and its mediated functions can provide a solid theoretical basis for CD226-targeted immunotherapy of tumors and autoimmune diseases.
Keywords：CD226signal transduction pathwayT cellsNK cellstumorautoimmune diseases
Publication Date：2024-09-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：6( 1071-1076 )