Role of SHIP1 in tumorigenesis,development and immune regulation
SHEN Yujie
XU Ying
YANG Hong
LI Jia
LI Yuanfeng
CHEN Zhihao
FENG Wangyou
CHEN Zijun
Abstract：The SH2-containing inositol 5'-phosphatase 1(SHIP1)is a kind of phosphatase proteins mainly but not completely expressed in the cytoplasm of hematopoietic cells.It belongs to the inositol 5'-phosphatase family and is an important negative regulator of phosphatidylinositol-3-kinase(PI3K)signal pathway.PI3K signal pathway has been proved to play a role in tumorigenesis and development.As a regulator of phosphoinositide signal pathway,SHIP1 plays an important role in tumorigenesis,development and immune regulation.The purpose of this review is to summarize the role of SHIP1 in tumorigenesis,development and immune regulation,in order to explore new ways of tumor treatment.
Keywords：SH2-containing inositol 5'-phosphatase 1tumorimmune regulation
Publication Date：2024-09-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：5( 1062-1066 )