Mechanism of Banxia Houpu decoction in treating gastroesophageal reflux disease and chronic pharyngitis with concept of"same treatment for different diseases"based on network pharmacology and molecular docking technology
LI Yan
WANG Jiehong
Abstract：Objective To explore the mechanism of Banxia Houpu decoction in treating gastroesophageal reflux disease(GERD)and chronic pharyngitis with concept of"same treatment for different diseases"in traditional Chinese medicine by network pharmacology and molecular docking technology.Methods The active ingredients and potential targets of Banxia Houpu decoction were retrieved from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,HERB and Encyclopedia of Traditional Chinese Medicine databases.The targets of GERD and chronic pharyngitis were obtained from GeneCards,TTD and OMIM databases.The common targets of herbs and diseases were screened through the Venny platform.The"herbs-active ingredients-common targets-diseases"network was established to demonstrate their interactions by Cytoscape 3.9.1 software.The PPI network of common targets was constructed by STRING.GO and KEGG enrichment analysis of common targets were carried out by Metascape platform.Schrödinger Suite was used to perform molecular docking of key targets and all active ingredients,verify the binding capacity of potential targets to herb ingredients,and screen out the main active ingredients.Results A total of 46 active ingredients of Banxia Houpu decoction and 223 herb targets were obtained.A total of 2 170 targets for GERD and 402 targets for chronic pharyngitis were obtained,and 59 common targets of diseases and herbs were screened out.The core targets involved IL-6,TNF,AKT1,IL-1β,VEGFA,etc.GO analysis showed that common targets were mainly involved in biological processes such as negative regulation of cell population proliferation,positive regulation of cell transport,and inflammatory response.The results of KEGG analysis showed that common targets were related to cancer pathway,JAK-STAT,NF-κB and other signaling pathways.The results of molecular docking showed that there were binding sites between core proteins and most of the active ingredients.Among them,quercetin,(+)-catechin,acanthoside B,baicalein,ellagic acid and other ingredients were stable in binding to core targets,which could be speculated to be the main ingredients of"same treatment for different diseases".Conclusion Banxia Houpu decoction can treat GERD and chronic pharyngitis with concept of"same treatment for different diseases"by inhibiting apoptosis,reducing inflammatory response and regulating immunity through multi-ingredient,multi-target and multi-pathway.
Keywords：Banxia Houpu decoctionnetwork pharmacologymolecular dockinggastroesophageal reflux diseasechronic pharyngitissame treatment for different diseases
Publication Date：2024-09-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：9( 1033-1041 )