Therapeutic effect of Houpu exhaust mixture combined with early enteral nutrition on severe acute pancreatitis

CHAI Xin; ZHANG Xijing; FANG Zongping

doi:10.13276/j.issn.2097-1656.2024.06.016

Abstract：Objective To study the effect and safety of Houpu exhaust mixture combined with early enteral nutrition on severe acute pancreatitis(SAP).Methods A total of 108 SAP patients admitted to Department of Critical Care Medicine,Xijing Hospital,Air Force Medical University from January 2017 to October 2022 were selected as subjects,and 58 patients were included in this study after screening.Retrospective analysis was performed on the therapeutic effects of the treatment regimen of early enteral nutrition based on conventional treatment of SAP(control group,n=33)and the treatment regimen of Houpu exhaust mixture combined with early enteral nutrition based on conventional treatment of SAP(treatment group,n=25).The time to bowel sound recovery,first bowel movement,continuous renal replacement therapy(CRRT),mechanical ventilation and ICU stay,and abdominal pressure,gastrointestinal dysfunction score and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score on the 3rd day of treatment were observed in the two groups.Results The time to bowel sound recovery,first bowel movement,and ICU stay in the treatment group were shorter than those in the control group(P＜0.05),but there was no significant difference in CRRT time and mechanical ventilation time between the two groups(P＞0.05).Compared with the control group,abdominal pressure,gastrointestinal dysfunction score and APACHE Ⅱ score on the 3rd day of treatment were lower in the treatment group(P＜0.05).Conclusion Houpu exhaust mixture combined with early enteral nutrition can improve the gastrointestinal function,reduce the severity of the disease,and improve the therapeutic effect of SAP patients.