Prognostic value of longitudinal inflammatory biomarkers in patients with esophageal squamous cell carcinoma receiving definitive chemoradiotherapy:a multicenter study
LI Jie
YANG Zhi
LI Jiacheng
ZHANG Cong
ZHAO Li'na
Abstract：Objective To investigate the relationship between longitudinal inflammatory biomarkers and prognosis in esophageal squamous cell carcinoma(ESCC)patients receiving definitive chemoradiotherapy(CRT),and to construct prognostic models by combining various indicators.Methods ESCC patients who received CRT at two hospitals were retrospectively included.Generalized estimating equation was used to evaluate the longitudinal differences of inflammatory biomarkers[systemic immune-inflammatory index(SII),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and lymphocyte-to-monocyte ratio(LMR)]among patients with different treatment responses.The inflammatory biomarkers were converted into categorical variables according to the optimal cut-off values.Kaplan-Meier curve was used to analyze the relationship between inflammatory biomarkers at different time points and overall survival(OS)and local recurrence-free survival(LRFS).LASSO regression and multivariable Cox proportional hazards regression were used to analyze independent risk factors and construct nomograms for predicting OS and LRFS in ESCC patients,respectively,to cross-validate the performance of the model.Results Patients with different treatment responses had significant interaction effects with longitudinal SII,NLR and PLR(P＜0.05).Inflammatory biomarkers before and after CRT,SII,NLR and PLR at week 2 of CRT,and PLR and LMR at week 4 of CRT were significantly correlated with OS and LRFS(P＜0.05).In multivariate survival analysis,PLR at week 2 and week 4 of CRT,and LMR at week 4 and after CRT were independent influencing factors for OS and LRFS(P＜0.05).Based on the variables in Cox regression analysis(P＜0.10),prediction models for OS and LRFS were established.After cross-validation,consistency indexes of the model were 0.666 and 0.665,respectively.Conclusion In addition to baseline,longitudinal inflammatory biomarkers during CRT can also serve as reliable biomarkers for ESCC patients.
Keywords：esophageal squamous cell carcinomainflammatory biomarkersprognostic prediction
Publication Date：2024-06-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：10( 686-694,698 )