Research progress on the therapeutic effects of exosomes from different sources on osteonecrosis of the femoral head
JIA Hong
CHEN Yongfeng
JIA Jing
SUN Qiang
FENG Yafei
ZHANG Dawei
ZHU Qingsheng
Abstract：Osteonecrosis of the femoral head(ONFH)is a common and frequently occurring disease in orthopedics,with an increasing incidence.The main pathogenesis is osteonecrosis due to impaired blood flow.Various treatment methods have been explored,but the outcomes are often unsatisfactory,which seriously affects the quality of life of patients.Exosomes,as vesicles secreted by cells,are abundant in a variety of bioactive components and play a crucial role in tissue repair and blood vessel formation through invasion,cell differentiation,and immune regulation.Studies have found that exosomes from different sources play a role in inhibiting osteocyte apoptosis and promoting angiogenesis.In this paper,the related studies of exosomes and ONFH are further reviewed,so as to provide reference and basis for the reversible treatment of ONFH.
Keywords：osteonecrosis of the femoral headexosomesosteocyteangiogenesis
Publication Date：2024-05-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：4( 578-581 )