Analysis of clinical effects and influencing factors of collagenase chemonucleolysis in the treatment of huge lumbar disc herniation
HU Longquan
SHI Xiaohua
LYU Zhuomin
ZHANG Hongxin
YUAN Peng
Abstract：Objective To investigate the effects of collagenase chemonucleolysis(CCNL)on huge lumbar disc herniation(HLDH)and analyze its influencing factors.Methods The clinical data of 159 HLDH patients who underwent CCNL in Tangdu Hospital,Air Force Medical University from January 2018 to December 2020 were retrospectively analyzed.According to the treatment effect two years after surgery,the patients were divided into effective group(n=131)and ineffective group(n=28),and univariate and multivariate analyses were performed.Results Two years after surgery,the overall excellent rate was 82.4％in 159 HLDH patients.Univariate analysis showed statistical differences in age,preoperative Visual Analogue Scale(VAS)of legs and segments of herniation between the two groups(P＜0.05).Multivariate regression showed that age and preoperative VAS of legs were independent factors affecting the efficacy of HLDH.Conclusion CCNL is an effective treatment for HLDH,and older age and lower preoperative VAS of legs are the main influencing factors for poor efficacy.
Keywords：collagenasechemonucleolysishuge lumbar disc herniation
Publication Date：2024-04-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：4( 436-439 )