Expression and clinical significance of TUBA1B in pan-cancer
LIU Yi
ZHOU Yelu
HE Wenfang
LU Yuanyuan
ZHAO Xiaodi
WU Kaichun
Abstract：Objective To illustrate the relationship between tubulin alpha-1B(TUBA1 B)and pan-cancer features through bioinformatics analysis.Methods Clinical data of cancer patients in TCGA database were used to explore the correlation between TUBA1 B and various cancer types from six aspects:expression levels,disease staging,prognosis,gene mutation characteristics,immune infiltration level and gene enrichment analysis.Results TUBA1 B was highly expressed in most cancers compared with adjacent non-tumor tissues(P<0.05).TUBA1 B showed early diagnostic value in 14 tumors,including invasive breast cancer(P<0.05),and late progression monitoring value in 3 renal tumors,including adrenocortical carcinoma(P<0.05).High expression of TUBA1B indicated a poor prognosis in multiple tumors(P<0.05).Immunoinfiltration analysis revealed that TUBA1 B was positively correlated with most immune-infiltrating cells and immune-related genes in pan-cancer(P<0.05).Gene enrichment analysis indicated that TUBA1 B may be involved in the development of tumor by regulating biological processes such as cell cycle,DNA damage repair,and mitosis.Conclusion TUBA1 B is involved in the occurrence,development and immunoinfiltration of a variety of tumors,which can be used as a tumor marker for pan-cancer and a potential drug target.
Keywords：tubulin alpha-1Bpan-cancertumor immunity
Publication Date：2024-03-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：10( 282-291 )