Analysis of prognostic factors of elderly patients undergoing radical resection for gastric cancer
DAN Hanjun
ZHENG Gaozan
TIAN Ye
FENG Fan
ZHENG Jianyong
Abstract：Objective To analyze the clinicopathological characteristics and prognosis of elderly patients with gastric cancer,so as to provide a therapeutic approach for clinical strategy development.Methods The clinicopathological data of patients with gastric cancer who were older than 70 years and underwent radical surgery in Xijing Hospital from August 2008 to December 2017 were retrospectively analyzed to study the relationship between different factors and prognosis.Results This study included 566 patients with an average age of 73.9 years,including 434 males(76.7%)and 132 females(23.3%).The median survival time of patients after surgery was 71.4 months,and the 5-year survival rate was 51.8%.Univariate analysis showed that preoperative albumin,carcinoembryonic antigen,carbohydrate antigen 125(CA125),carbohydrate antigen 19-9,alpha-fetoprotein,mode of gastrectomy,tumor size,degree of differentiation,T stage,N stage,intraoperative blood loss,lymphovascular invasion,and perineural infiltration were correlated with the prognosis of elderly patients with gastric cancer(P<0.05).Multivariate analysis showed that tumor size,T stage,N stage,intraoperative blood loss,lymphovascular invasion,perineural infiltration,and preoperative CA125 were independent prognostic factors of elderly patients with gastric cancer(P<0.05).Survival analysis showed that patients with tumor size≥4 cm,deeper infiltration depth,more metastatic lymph nodes,intraoperative blood loss≥250 mL,preoperative CA125 abnormality,lymphovascular invasion and perineural infiltration had a worse prognosis(all P<0.05).Conclusion Preoperative serum CA125 levels,tumor size,intraoperative blood loss,T stage,N stage,lymphovascular invasion and perineural infiltration are important prognostic indicators in elderly patients with gastric cancer after radical resection.
Keywords：gastric cancerelderly patientsgastrectomyprognostic indicators
Publication Date：2024-03-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：5( 277-281 )