Prognostic role of inflammatory markers in patients with primary biliary cholangitis
WANG Kemei
TIAN Siyuan
SHANG Yulong
HAN Ying
Abstract：Objective To investigate whether inflammatory markers can predict the prognosis of patients with primary biliary cholangitis(PBC).Methods A retrospective study was conducted to explore the correlation between inflammatory markers and liver function through Spearman correlation analysis.The optimal cut-off value of inflammatory markers was determined by X-tile software.The effects of each inflammatory marker on prognosis were compared by Log-rank test and their respective Kaplan-Meier curves were drawn,and finally the inflammatory markers affecting prognosis were further analyzed by Cox survival analysis.Results The gamma-glutamyl transpeptidase-to-platelet ratio(GPR)was an independent risk factor for the prognosis of PBC patients,and higher GPR(≥1.9)prompted a poor prognosis.Conclusion GPR level at baseline has a correlation with the histological stage and poor prognosis of PBC patients.GPR(≥1.9)can be utilized as an independent predictor to suggest negative prognosis of PBC patients.
Keywords：inflammatory markersprimary biliary cholangitisprognosis
Publication Date：2024-03-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：7( 251-256,262 )