Hyperactivation of cochlear nucleus neurons in mice with military aviation noise-induced hidden hearing loss
ZHU Jing
JIANG Yihong
WU Kan
ZHENG Zeyu
ZHANG Peng
CHANG Tong
ZHANG Zhuoru
WANG Fei
WANG Haotian
ZHANG Min
WANG Xiaocheng
Abstract：Objective To construct mouse models of hidden hearing loss(HHL)and noise-induced hearing loss and analyze the effects of military aviation noise exposure on the activation state of cochlear nucleus neurons in mice.Methods Male C57 mice with normal hearing were randomly divided into 3 groups and given 110 dB 2 h noise,115 dB 4 h noise and no noise exposure,respectively.Auditory brainstem response(ABR)tests and immunofluorescence staining of c-Fos protein in mouse cochlear nuclei were performed at 1,7,14 and 28 d after noise exposure.Results After noise exposure,the auditory threshold of the mice in HHL group experienced a temporary threshold shift,with a decrease in ABR Ⅰamplitude of supraliminal stimuli and an increase in the number of positive neurons expressing c-Fos protein in the cochlear nucleus.Conclusion Military aviation noise-induced HHL in mice is characterized by a temporary shift in auditory thresholds,a decrease in ABR Ⅰ wave amplitude of supraliminal stimuli,and hyperactivation of cochlear nucleus neurons.
Keywords：hidden hearing lossmilitary aviation noiseauditory brainstem responsecochlear nucleusc-Fos protein
Publication Date：2024-02-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：6( 169-174 )