Application of butorphanol combined with dexmedetomidine in patients with severe acute pancreatitis
LI Jin
ZHANG Xijing
FANG Zongping
CHAI Xin
Abstract：Objective To discuss the analgesic and sedative effects of butorphanol combined with dexmedetomidine in patients with severe acute pancreatitis(SAP).Methods Sixty-three SAP patients who met the inclusion criteria admitted to Department of Critical Care Medicine,Xijing Hospital,Air Force Medical University from January 2017 to October 2022 were included in this study.Analgesic,sedative,and prognostic effects of patients between group A(butorphanol combined with dexmedetomidine,n=28)and group B(fentanyl combined with dexmedetomidine,n.=35)were observed.Heart rate,respiratory rate,Richmond Agitation-Sedation Scale(RASS)score,Critical-Care Pain Observation Tool(CPOT)score,and gastric residual volume were compared between the two groups.Results Statistical analyses showed that heart rate,respiratory rate,CPOT score,RASS score and gastric residual volume in group A were lower than those in group B,and the differences were statistically significant[(82.16±7.41)times/min vs(104.64± 10.30)times/min,(19.43±3.92)times/minvs(27.18±4.21)times/min,(0.94±0.31)points vs(2.32±0.35)points,(1.20±0.44)points vs(0.91±0.47)points,and(89.74±12.28)mL vs(142.43±18.57)mL].Conclusion For SAP patients,butorphanol combined with dexmedetomidine has definite and effective analgesic and sedative effects,with fewer complications,better clinical therapeutic effects and stable hemodynamics,which is worthy of clinical application.
Keywords：butorphanoldexmedetomidinefentanylsevere acute pancreatitis
Publication Date：2024-01-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：4( 89-92 )