Current status and research progress of animal thymokidney model construction
WANG Zhaoxiang
WEI Fanchao
HUANG Dayuan
HAN Shichao
QI Ruochen
WANG Guohui
ZHANG Xiaoyan
LIU Kepu
MA Shuaijun
YANG Xiaojian
QIN Weijun
Abstract：Worldwide,for patients with end-stage organ failure,a major limitation of allogeneic organ transplantation is the shortage of donor organs.Xenotransplantation is a new research direction to solve the problem of organ shortage,but the rejection and virus infection after xenotransplantation are serious problems.Existing studies have shown that using thymus transplantation as an auxiliary means to construct animal thymokidney model during xenotransplantation can effectively reduce the occurrence of rejection.This paper mainly introduces the main characteristics of thymus,the construction of thymokidney model and the effect of thymokidney in establishing immune tolerance in xenotransplantation model.The thymokidney model was used to establish immune tolerance in 2 reported clinical trials of xenotransplantation,and the postoperative data showed that thymokidney could reduce rejection in clinical xenotransplantation.However,there is still no breakthrough in the research on the mechanism of immune tolerance of thymokidney,and more exploration is still needed in basic research in the future,in order to provide more precise theoretical basis for clinical application.
Keywords：xenotransplantationthymusthymokidneyimmune tolerance
Publication Date：2024-01-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：5( 39-42,47 )