Breakthroughs and problems in subclinical research of solid organ xenotransplantation
LIU Xin
DU Jiaxiang
HUAI Guoli
XING Xiangyang
XIE Yuxuan
PAN Dengke
Abstract：Solid organ xenotransplantation refers to an exploratory therapeutic technique in which solid organs such as heart,kidney,and liver from non-human donors are transplanted into human recipients.Currently,survival records of 2 to 3 years have been obtained in animal models of solid organ xenotransplantation of non-human primates derived from heterogenous gene-edited pig kidneys and hearts.Consequently,further improving the way and effect of gene editing and advancing xenotransplantation to clinical application has become a hot spot in organ transplantation.From 2021 to 2023,international research teams have conducted more than 10 subclinical studies on kidney and heart transplantation of gene-edited pig-to-brain-dead decedents,none of which showed hyperacute rejection.This paper reviews the results of 7 studies on subclinical xenotransplantation and 2 cases of pig heart transplantation reported in recent years,and discusses the problems to be solved in heart and kidney xenotransplantation,so as to provide some references for the clinical research of xenotransplantation in China.
Keywords：xenotransplantationnon-human primateheart transplantationkidney transplantationrejection reaction
Publication Date：2024-01-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：4( 35-38 )