Study on the therapeutic mechanism of Ruyi Jinhuang Powder on necrotizing fasciitis based on network pharmacology
LIU Yongsheng
ZHAO Hui
XUE Xiaoyan
JIA Min
ALAMUSI
JIANG Chao
ZHANG Xi
LI Mingkai
Abstract：Objective To study the mechanism of action of Ruyi Jinhuang Powder on necrotizing fasciitis by network pharmacology.Methods The potential components and possible targets of Ruyi Jinhuang Powder and necrotizing fasciitis were collected from TCMSP and DrugBank databases,and their intersection was selected.The"herb-component-target"interaction network was constructed using Cytoscape software.The protein interaction networks were constructed in STRING database,and core targets of Ruyi Jinhuang Powder were screened.GO and KEGG were used to analyze the mechanism of action of Ruyi Jinhuang Powder in the treatment of necrotizing fasciitis,and molecular docking was used to validate the ability to predict affinity between components and core targets.Results Ruyi Jinhuang Powder could treat necrotizing fasciitis through 44 targets,the core targets of which were mainly ALB,IL-6,TNF,INS,STAT3,and PTGS2.It could inhibit acute inflammatory response,cytokine regulation,and endotoxin response through IL-17,TNF,NF-κB and other signaling pathways,and the active ingredients of Ruyi Jinhuang Powder had good affinity with predicted targets.Conclusion Ruyi Jinhuang Powder can treat necrotizing fasciitis through"multi-target-multi-pathway"approach.This study provides a theoretical basis for the clinical application of Ruyi Jinhuang Powder in the treatment of necrotizing fasciitis.
Keywords：Ruyi Jinhuang Powdernecrotizing fasciitisinflammationnetwork pharmacology
Publication Date：2023-12-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：6( 1197-1202 )