Anxiety and depression lead to fALFF changes in migraine patients:an fMRI cross-sectional study
CHEN Zhuhong
XU Qiang
YANG Guan
ZHANG Chi
SUN Jingting
SHANG Yuxuan
HU Bo
WANG Wen
Abstract：Objective To investigate the effects of anxiety and depression on brain functional alterations in migraine patients.Methods Resting-state functional magnetic resonance imaging data were used to analyze the changes in fractional amplitude of low-frequency fluctuation(fALFF)in 46 patients with migraine without aura and 34 age-and gender-matched healthy controls.Pearson correlation analysis was used to explore the relationship between changes in fALFF and clinical characteristics.Results The fALFF value of the posterior lobe of left cerebellum increased in migraine patients with or without anxiety and depression.In patients with migraine without anxiety and depression,decreased fALFF values were found in the thalamus,temporal lobe,and frontal lobe.In patients with migraine with anxiety and depression,fALFF value in cerebellum was negatively correlated with the Montreal Cognitive Assessment scores.Conclusion The posterior lobe of left cerebellum is a continuously activated region in migraine patients.This region may be a target region for further understanding the mechanism of migraine attack.
Keywords：migrainemagnetic resonance imagingfractional amplitude of low-frequency fluctuationdepression
Publication Date：2023-02-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：6( 105-110 )