The appearance of amyloid is not the essence
GENG Lijun
XIAO Jianlong
CHEN Yinling
ZHAO Hailu
Abstract：A soluble amyloid protein can aggregate as fibrilla deposits with characteristic cross β-sheet structure. Patients with type 2 diabetes frequently have islet amyloid and persons with Alzheimer's dementia commonly show amyloid plaque in their brains. Whether amyloid deposition is pathogenic or physiological remains unknown in clinical medicine and experimental research. Here we use amyloid as an example to explore the limitations of using eyes, microscopes and light waves. Furthermore, scientists themselves also have inherited limitations in recognizing the true nature of amyloid. The same amyloid protein manifests totally different characteristics from the perspectives of men, bacteria and other creatures. Therefore, we propose to avoid any overuse of medical facilities and technologies in both clinical practice and basic research. In order to understand the true nature, the limitations of tools, methods and examiners should be kept in mind when making decision and diagnosis based on the data obtained from personal observation.
Keywords：amyloidhistochemical stainingimmunohistochemical stainingmicroscopeelectromagnetic wave
Publication Date：2018-01-01
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：5( 55-59 )