Is AMP-activated protein kinase a protective factor in inflammatory injury?
DAI Jie
ZHANG Xiaoming
ZHANG Li
Abstract：AMP-activated protein kinase (AMPK) is pivotal cellular metabolic regulatory enzyme. It exerts extensive anti-inflammatory effects in inflammatory response that is an energy intensive process. Our and other labs have previously found that the pretreatment with AMPK activators have profound beneficial effects in various animal models with inflammatory disorders. However, the pre-insult intervention is unpractical in clinic patients. In our recent study, we unexpectedly found that the post-insult treatment with AMPK activators aggravated fulminant hepatitis, whereas the posttreatment with AMPK inhibitors alleviated liver injury. Our study also found that AMPK was mainly activated at the late stage in the progression of fulminant hepatitis, which promoted cell apoptosis via the activation of JNK. These studies suggest that AMPK might have dual effects, including anti-inflammatory and pro-apoptotic activities, at different stages during the progression of inflammatory disorders. Thus, whether the AMPK activators or the AMPK inhibitors should be used for the intervention of inflammatory injury requires careful reconsideration.
Keywords：AMP-activated protein kinaseenergy sensorinflammationapoptosis
Publication Date：2018-05-02
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：4( 15-18 )