Analysis of MRI imaging characteristics of mass-type breast cancer with different molecular subtypes
ZHANG Zhoufang
YIN Anyu
PENG Xuehua
ZENG Ling
ZHANG Yuzhong
E Linning
Abstract：Objective To explore the MRI imaging features of mass breast cancer with different molecular subtypes.Methods A total of 110 patients with mass-type breast cancer were selected and classified into molecular subtypes based on his-topathological examination,including 22 cases of HER-2 overexpressing type,35 cases of Luminal A type,38 cases of Luminal B type,and 15 cases of triple-negative type.Imaging data and clinicopathological data of the patients were collected.Age,histo-logical grade,maximum tumor diameter,morphological features,ADC values,and enhancement curve patterns were compared among patients with different molecular subtypes of mass-type breast cancer.Multivariate logistic regression analysis was em-ployed to screen for imaging characteristics associated with molecular subtypes.Results There was a statistically significant dif-ference between different molecular subtypes of breast cancers in terms of histological grade,maximum tumor diameter,spicula-tion sign,internal enhancement pattern,and ADC values(all P<0.05),among these,triple-negative breast cancer had the high-est proportion of Grade Ⅲ tumors,maximum tumor diameter>2 cm,and rim enhancement pattern.The spiculation sign was most common in the Luminal subtype,while HER-2 overexpressing subtype exhibited the highest ADC values.The differences in age of onset,lymph node metastasis,and tumor margins,morphology,lobulation sign,and curve type of different molecular subtypes of breast cancer were not statistically different(all P>0.05).Multi classification logistic regression analysis showed that the internal enhancement pattern was an independent risk factor in Luminal B(OR=6.711,95%CI:1.700-26.497,P<0.01),Luminal A(OR=5.072,95%CI:1.229-20.936,P<0.05),HER-2 positive(OR=9.132,95%CI:2.105-39.609,P<0.01).The spiculated sign was an independent risk factor for Luminal A(OR=9.604,95%CI:1.822-50.630,P<0.01).Conclusion The MRI imaging of mass breast cancer show certain differences among different molecular subtypes.Particular attention should be paid to tumor size,spiculated sign,internal enhancement pattern,and ADC value.
Keywords：Magnetic resonance imagingBreast cancerMolecular subtypes
Publication Date：2026-01-30
Online Publishing Date：2026-03-20(First online date of this platform, not the publication date of the document)
Pages：6( 55-59,86 )