Characteristics of shear wave elastography and the difference of ANXA6 mRNA expression in patients with breast can-cer and its clinical value in predicting prognosis

ZHANG Rongxin; WEI Jie; WANG Wei; LIN Yu; ZHOU Meng

doi:10.20258/j.cnki.1006-9011.2026.01.008

Abstract：Objective To investigate the characteristics of shear wave elastography(SWE)and the difference of exo-somal annexin A6(ANXA6)mRNA expression in patients with breast cancer and its clinical value in predicting prognosis.Methods A total of 240 patients with breast cancer were selected.According to the results of immunohistochemical staining,they were assigned into 90 cases of Luminal A type,76 cases of Luminal B type,33 cases of HER-2 overexpression type and 41 cases of TNBC type.All patients received SWE examination after admission,and the relative expression of ANXA6 mRNA in breast cancer tissues was detected.The patients were followed up regularly,according to the prognosis,they were divided into patients with good prognosis and poor prognosis.The quantitative parameters of SWE and the expression of ANXA6 mRNA in pa-tients with different molecular subtypes of breast cancer were compared.By the end of follow-up,the prognosis and survival of breast cancer patients were counted.The clinicopathological data,SWE quantitative parameters and ANXA6 mRNA expression in tumor tissues of patients with different prognosis were compared.Logistic regression equation was used to analyze the influenc-ing factors of breast cancer patients.ROC was used to analyze the prognostic value of SWE quantitative parameters and ANXA6 mRNA in breast cancer patients.Results Compared with HER-2 overexpression type,Luminal B type and Luminal A type,Emax,Emean,and Emin of TNBC type were higher,and ANXA6 mRNA was lower(P<0.05).By the end of follow-up,the overall survival rate of breast cancer patients was 74.35%,and the overall survival rate of TNBC was 48.78%.There were significant dif-ferences in tumor stage,lymph node metastasis,Emax,Emean,Emin and ANXA6 mRNA expression in patients with different progno-sis(all P<0.05).Logistic regression analysis showed that ANXA6 mRNA,Emax,Emean,and Emin were still the prognostic factors of breast cancer patients after adjusting for tumor stage and lymph node metastasis(all P<0.05).The ROC curve showed that the area under the curve(AUC)of Emax,Emean,Emin and ANXA6 mRNA in predicting the prognosis of breast cancer patients was 0.872(95%CI:0.734-0.947),which was higher than that of single prediction(P<0.05).Conclusion The quantitative param-eters of SWE and ANXA6 mRNA are abnormal in patients with TNBC breast cancer,both of which are the influencing factors of poor prognosis of breast cancer.The combined detection has certain predictive value for poor prognosis,which can be used as an auxiliary scheme for clinical judgment of pathological types and prediction of prognosis,which can guide clinical work.