Correlation between arterial arrival time assessed by dual PLD ASL and the cerebral white matter hyperintensity volume
CAO Zhenyu
WANG Jian
XU Zhihua
GONG Wanfeng
CAO Yulin
Abstract：Objective To explore the correlation between cerebral white matter hyperintensities(WMHs)volume and changes in arterial arrival time(ATT)assessed by dual post-labeling delay(PLD)arterial spin labeling(ASL).Methods 92 patients with cerebral small vessel disease were selected.All patients underwent routine MRI and ASL scans with dual PLD.PLD was 1.6 s and 2.5 s,respectively.The volumes of WMHs,WMHs region,non-WMHs cerebral white matter(NAWM)region,cerebral cortex(GM)cerebral blood flow(CBF),ΔCBF were calculated.The relationship between different PLD CBF and ΔCBF with WMHs volume was analyzed.Results When PLD=1.6 s,WMHs and GM CBF were negatively correlated with WMHs volume(r was-0.570,-0.229,respectively,P<0.05).When PLD=2.5 s,WMHs,NAWM,and GM CBF were not cor-related with WMHs volume(P>0.05).WMHs ΔCBF,NAWMΔCBF,and GMΔCBF were all correlated with WMHs volume(r was 0.624,0.275,0.348,respectively,P<0.05).Conclusion ATT prolongation reflected by ΔCBF derived from dual-PLD ASL is associated with WMHs volume,whereas,CBF assessment based on a single PLD has limitations in characterizing WMHs-related perfusion abnormalities.
Keywords：Magnetic resonance imagingArtery arrival timeDual post-labeling delayArterial spin labelingCerebral blood flowWhite matter hyperintensities
Publication Date：2026-01-30
Online Publishing Date：2026-03-20(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )