The value of magnetic resonance imaging in assessing white matter microstructure changes and neurocognitive dysfunc-tion in OSAS patients with obesity
HU Deyu
SU Xintong
LIU Chaopeng
SU Miaoshang
ZHANG Zhijin
DONG Wenxi
LIN Quanren
Abstract：Objective To investigate the microstructural changes of magnetic resonance cerebral white matter and neurocog-nitive disorders in patients with obstructive sleep apnea syndrome(OSAS)and obesity.Methods Thirty patients each with non-OSAS and OSAS diagnosed by polysomnography(PSG)were selected.Serum brain-derived neuotrophyic factor(BDNF)de-tection and Montreal Cognitive Assessment(MoCA)were investigated to confirm neurocognitive dysfunction.Routine MRI scan-ning and diffusion tensor imaging(DTI)of the head were performed on all the patients.DTI analysis was conducted on the rel-evance of fractional anisotropy(FA),mean diffusivity(MD),axial diffusivity(AD),radial diffusivity(RD)and all the clinical index.Results Compared with the obese patients in the non-OSAS group,the FA values of some brain regions of the obese pa-tients in the OSAS group decreased(P<0.01),the MD values increased(P<0.05),the AD values decreased(P<0.05),and the RD values increased(P<0.05).The lesions of these patients were mainly located in brain white matter fibers,such as the bilat-eral corona radiata,the bilateral anterior and posterior limbs of the internal capsule,the bilateral cingulate gyrus,and the cor-pus callosum.Correlation analysis showed that FA value was correlated with MoCA,and serum BDNF level was also correlated with MoCA(all P<0.01).Conclusion The cerebral white matter microstructure changes in FA,MD,AD,and RD values were found in OSAS patients.The decrease of FA value and serum BDNF level might be related to neurocognitive dysfunction.
Keywords：Magnetic resonance imagingDiffusion tensor imagingObstructive sleep apnea syndromeObesityCerebral white matter microstructureCognitive function
Publication Date：2025-09-30
Online Publishing Date：2025-10-29(First online date of this platform, not the publication date of the document)
Pages：6( 5-10 )