The application value of minimum ADC value in diffusion-weighted magnetic resonance imaging for grading diagnosis and evaluation of tumor cell proliferation activity in pediatric gliomas
SU Xiaoran
CHEN Wan
YANG Kaihua
NIE Lei
SHI Shengli
Abstract：Objective To explore the application value of the minimum apparent diffusion coefficient(ADC)value of mag-netic resonance diffusion-weighted imaging(DWI)in the grading diagnosis of glioma in children and the evaluation of tumor cell proliferation activity.Methods A total of 95 children with glioma were selected and divided into the low-grade(45 cases of grade Ⅰ and 15 cases of grade Ⅱ)and the high-grade(21 cases of grade Ⅲ and 14 cases of grade Ⅳ)according to the classifi-cation criteria of the central nervous system of the WHO.MRI examination was performed before the operation,and the minimum ADC value of the solid part of the tumor was measured on the ADC image with a b value of 1 000 s/mm2.The lesion tissue speci-mens resected by surgery were selected,pathological sections were prepared,immunohistochemical staining was performed,and the Ki-67 index was calculated.Results The minimum ADC value of 95 cases of pediatric glioma ranged from 0.490×10-3 to 2.039×10-3 mm2/s.Among them,the minimum ADC value of low-grade glioma in children was 0.708×10-3 to 2.039×10-3 mm2/s,and that of high-grade glioma in children was 0.490×10-3 to 0.860×10-3 mm2/s.The minimum ADC value of low-grade glioma in children was higher than that of high-grade glioma in children(Z=-7.840,P<0.05).Receiver operating characteristic curve analysis revealed that the area under the curve of the minimum ADC value for diagnosing high-grade glioma in children was 0.981(95%CI:0.955-0.994,P<0.05),the optimal cut-off value was 0.982×10-3 mm2/s.At this time,its sensitivity for diagnosing high-grade glioma in children was 94.9%and its specificity was 100.0%.Spearman correlation analysis showed that the minimum ADC value was negatively correlated with the Ki-67 index of glioma in children(r=-0.652,P<0.05).Conclusion The mini-mum ADC value in magnetic resonance DWI has certain value in the grading diagnosis of glioma in children,which can also re-flect the proliferation activity of tumor cells,playing an auxiliary role in prognosis evaluation.
Keywords：Magnetic resonance imagingDiffusion-weighted imagingApparent diffusion coefficientGliomaChildren
Publication Date：2025-09-30
Online Publishing Date：2025-10-29(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )