Clinical efficacy and safety of thermosensitive hydrogel in transcatheter arterial chemoembolization for the treatment of primary liver cancer
SHANG Jiannan
ZHAO Wenjing
ZHAO Zengwen
WANG Dandan
ZHENG Xu
NIU Defang
FAN Qingyong
GE Liping
Abstract：Objective To evaluate the effectiveness and safety of thermosensitive hydrogel for transcatheter arterial chemo-embolization(TACE)in the treatment of primary liver cancer.Methods Twenty-five patients with clinically confirmed unre-sectable advanced hepatocellular carcinoma who were receiving their first TACE treatment were selected.A thermosensitive hy-drogel was used during the procedure.The medium-and long-term prognosis was assessed according to the mRECIST criteria,and postoperative adverse reactions were recorded.Results All patients successfully completed the TACE procedure for liver cancer.Postoperative adverse reactions mainly included gastrointestinal reactions,pain,and fever,which were mild in severity.No patients experienced serious complications such as liver rupture or liver abscess,nor were there any treatment-related deaths.The objective response rates(ORR)at 1,3,and 6 months after treatment were 80.0%,63.6%,and 38.9%,respec-tively,while the disease control rates(DCR)were 92.0%,86.4%,and 72.3%,respectively.The median overall survival(mOS)was 13 months,and the median progression-free survival(mPFS)was 7 months.Conclusion Thermosensitive hydro-gel for transcatheter arterial chemoembolization in the treatment of primary liver cancer is safe and feasible,with significant clinical efficacy.
Keywords：Thermosensitive hydrogelPrimary liver cancerTranscatheter arterial chemoembolizationInterventional radiology
Publication Date：2025-07-30
Online Publishing Date：2025-08-26(First online date of this platform, not the publication date of the document)
Pages：4( 83-86 )