Application of arterial spin labeling imaging in cerebrovascular reserve in patients with hypertension
LI Jinglong
XUE Yongjie
LI Yishan
ZHAO Fanhui
Abstract：Objective To investigate the application value of multiple post-labeling delay(PLD)arterial spin labeling(ASL)imaging in evaluating cerebrovascular reserve in hypertensive patients with different blood pressure control levels.Methods Sixty-two patients with hypertension were examined on ASL,T1WI,T2WI,Flair and DWI.According to the blood pressure control levels,patients were divided into poorly controlled blood pressure group(G1 group)and well controlled blood pressure group(G2 group).Cerebral blood flow(CBF)was measured in frontal lobe,parietal lobe,temporal lobe,occipital lobe,insula,lentiform nucleus,cerebellum,thalamus,and pons.The difference of CBF in different PLD in the same region of G1 group and G2 group was compared by repeated measure analysis of variance,and the CBFPLD differences in the same region between G1 and G2 groups were compared.Results Among the 62 patients,36 were in the G1 group and 26 were in the G2 group.Pairwise comparison results showed that CBF2.5 and CBF2.0 were higher than CBF1.5 in each lobe,lentiform nucleus,and cerebellum in the G1 group(P<0.001),while,there was no significant difference between CBF2.5 and CBF2.0 in those regions(P>0.05).CBF2.5 and CBF2.0 were higher than CBF1.5 in each lobe,lentiform nucleus,and cerebellum in the G2 group(P<0.001),and CBF2.5 was higher than CBF2.0 in those regions(P<0.05).CBF2.5 was higher than CBF1.5 in thalamus and pons in the G2 group(P<0.05).CBF1.5,CBF2.0 and CBF2.5 in each lobe,lentiform nucleus,and cerebellum in the G1 group were lower than those in the G2 group(P<0.05).CBF2.5 in thalamus and pons in the G1 group were lower than those in the G2 group(P values were 0.008 and 0.025,respectively),while CBF1.5 and CBF2.0 in the thalamus and pons were not significantly different between the two groups(P>0.05).Conclusion Compared with the poorly controlled blood pressure group,the well-controlled blood pressure group had higher CBF and sufficient cerebral blood flow compensation,and multi-PLD ASL could provide important basis for clinical hypertension management and prevention of cerebrovascular diseases.
Keywords：HypertensionArterial spin labelingMagnetic resonance imagingCerebral blood flow
Publication Date：2025-07-30
Online Publishing Date：2025-08-26(First online date of this platform, not the publication date of the document)
Pages：5( 9-13 )