Application value of low-dose CT perfusion combined with low-concentration contrast agent in diagnosis of acute cere-bral infarction
ZHANG Wenxuan
YUE Kuitao
WANG Xizhen
MA Wenwen
MING Qianqian
LIU Ming
Abstract：Objective To investigate the application value and optimization strategy of low-dose CT perfusion imaging com-bined with low-concentration contrast agent in the diagnosis of acute cerebral infarction.Methods 84 patients with acute cere-bral infarction were selected.Patients were randomly divided into low-dose group(n=42)and conventional-dose group(n=42).The low-dose group was adopted 70 kV tube voltage,150 mAs tube current,and low-concentration contrast agent(320 mgI/mL);the conventional-dose group was used 120 kV tube voltage,250 mAs tube current,and 370 mgI/mL contrast agent.CT dose in-dex(CTDIvol),dose length product(DLP),effective dose,and perfusion parameters,such as cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT),time to peak(TTP),were compared between the two groups.ROC curve analysis was used to evaluate the diagnostic efficiency of the low-dose protocol.Results The CTDIvol,DLP,and effec-tive dose in the low-dose group were reduced by 61.8%,53.6%,and 58.2%,respectively(t=74.95,37.15,44.24,all P<0.001).ROC curve analysis showed that TTP had the best diagnostic performance with AUC of 0.860(95%CI:0.774-0.947),followed by MTT with AUC of 0.853(95%CI:0.765-0.941).AUC values for CBF and CBV were 0.811(95%CI:0.705-0.917)and 0.810(95%CI:0.703-0.916),respectively.Conclusion Low-dose CT perfusion imaging combined with low-concentration contrast agent maintains reliable diagnostic efficiency,while significantly reducing radiation dose,thereby making it a viable op-timization protocol for diagnosing acute cerebral infarction.
Keywords：Acute cerebral infarctionTomographyX-ray computedContrast medium
Publication Date：2025-07-30
Online Publishing Date：2025-08-26(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )