Comparative observation of signal intensity in hepatobiliary phase of gadoxetate disodium(Gd-EOB-DTPA)enhanced MRI for hepatocellular carcinoma patients with different differentiation grades
MA Zhenbo
LIU Zhiqiang
KONG Xue
KANG Qi
CAO Ting
XIE Yuanzhong
LI Xiujuan
Abstract：Objective To clarify the relationship between signal intensity in hepatobiliary phase and differentiation grades of hepatocellular carcinoma(HCC)by comparing tumor signal intensity in gadoxetate disodium(Gd-EOB-DTPA)enhanced MRI examinations.Methods We selected 52 pathologically confirmed HCC patients who underwent Gd-EOB-DTPA enhanced MRI within 3 weeks before surgery,including 13 well-differentiated,21 moderately-differentiated,and 18 poorly-differentiated cases.Signal intensities of normal liver parenchyma,tumors,and ipsilateral erector spinae muscle were measured in pre-contrast and hepatobiliary phase sequences.Relative signal intensity(rSI),enhancement rate(ER),and relative enhancement rate(rER)of tumors were calculated and compared among different differentiation groups.Results The tumor rSI values were 47.06%±7.27%,30.95%±8.83%,and 25.53%±4.72%for well-differentiated,moderately-differentiated,and poorly-differentiated HCCs,respectively.Corresponding ER values were 92.03%±6.43%,64.76%±7.01%,and 50.92%±80.62%,while rER values were 754.25%±189.56%,403.82%±158.37%,and 294.78%±67.93%.Well-differentiated HCCs showed significantly higher rSI,ER,and rER than moderately-differentiated and poorly-differentiated groups(all P<0.05).Moderately-differentiated HCCs also demonstrated higher values than poorly-differentiated cases(all P<0.05).Conclusion The signal intensity in hepatobiliary phase of Gd-EOB-DTPA enhanced MRI correlates with HCC differentiation grades,with higher signal intensity,indicating better tu-mor differentiation.
Keywords：Magnetic resonance imagingGadoxetate disodiumHepatocellular carcinomaDegree of differentiation
Publication Date：2025-06-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 91-93,98 )