Predictive value of multishot diffusion imaging-base multiplexed sensitivity encoding intravoxel incoherent motion and non-contrast enhanced T1 mapping quantitative parameters for transcatheter arterial chemoembolization of hepatocel-lular carcinoma

DONG Yaning; ZHU Jufang; DUAN Jinhui; REN jipeng; MAO Ke; HAN Dongming

doi:10.20258/j.cnki.1006-9011.2025.06.018

Abstract：Objective To explore the predictive value of quantitative parameters by multishot diffusion imaging-base multi-plexed sensitivity encoding intravoxel incoherent motion(MUSE-IVIM)and non-contrast-enhanced T1 mapping-enhanced in transcatheter arterial chemoembolization(TACE)for hepatocellular carcinoma(HCC).Methods Sixty-four patients with pri-mary liver cancer were selected and followed up for 3-6 months after TACE treatment.According to the modified evaluation crite-ria for solid tumor efficacy,they were divided into a good response group(28 cases)and a poor response group(36 cases).MUSE-IVIM and T1 mapping scans were performed 1 to 2 weeks before TACE treatment.The MUSE-IVIM quantitative param-eters in terms of standard apparent diffusion coefficient(standard ADC),slow apparent diffusion coefficient(slow ADC),fast apparent diffusion coefficient(fast ADC),perfusion fraction(f),water molecular diffusion distribution index(DDC),diffusion heterogeneity index(α),and T1 mapping quantitative parameters initial intra tumoral and peritumoral longitudinal relaxation time(T1)values were obtained.Quantitative parameters of MUSE-IVIM and T1 mapping were compared between the two groups.Multivariate Logistic regression model was used to screen the risk factors associated with TACE treatment,and the predictive effi-cacy was evaluated by receiver operating characteristic(ROC)curve.Results There were significant differences in standard ADC and slow ADC values of MUSE-IVIM quantitative parameters between the two groups(P<0.05).There were no significant differences in MUSE-IVIM quantitative parameters such as fast ADC value,f value,DDC value,α value,initial intratumoral T1 value and initial periatumoral T1 value(P>0.05).Multivariate Logistic regression analysis showed that standard ADC value and slow ADC value were independent risk factors for predicting TACE treatment effect of liver cancer(P<0.05).ROC curve analysis showed that the AUC of standard ADC value,slow ADC value and their combination in predicting TACE treatment effect of liver cancer were 0.85,0.86 and 0.89,respectively.Although the combination of standard ADC value and slow ADC value predicted the AUC of TACE treatment effect of liver cancer,the difference was not statistically significant(P>0.05).Conclusion MUSE-IVIM quantitative parameters standard ADC value and slow ADC value have good predictive value for TACE treatment of liver cancer,but non-contrast enhanced T1 mapping technology can not predict the TACE treatment effect of liver cancer.