Differential diagnosis value of thin-walled cystic lung cancer and thin-walled cavity pulmonary tuberculosis using MSCT combined with serum tumor markers

SONG Huiling; WANG Mei; ZHANG Zheen; ZHANG Wenqi; MAO Qiong

doi:10.20258/j.cnki.1006-9011.2025.05.012

Abstract：Objective To explore the differential diagnostic efficacy of multi-slice spiral computed tomography(MSCT)com-bined with serum tumor markers for thin-walled cystic lung cancer and thin-walled cavitary pulmonary tuberculosis.Methods We selected 41 patients with thin-walled cystic lung cancer and 44 patients with thin-walled cavitary pulmonary tuberculosis con-firmed by pathological examination or sputum smear examination admitted to our hospital,and recorded them as the lung cancer group and tuberculosis group,respectively.Then,we compared the MSCT imaging results of two groups with serum tumor marker levels,and analyzed the differential diagnostic value of receiver operating characteristic(ROC)curves for thin-walled cystic lung cancer and thin-walled cavitary pulmonary tuberculosis.Results The diameter of the cavity in the lung cancer group was larger than that in the tuberculosis group(P<0.05).The proportion of patients with smooth inner walls,wall calcifica-tion,patchy inflammation,mediastinal lymph node calcification,and satellite lesions in the lung cancer group was lower than that in the tuberculosis group(P<0.05).The proportion of patients with rough outer wall,wall nodules,lobulation sign,spicula-tion sign,eccentric cavity,pleural depression sign,pleural adhesions,ground glass sign,and vascular bundle sign in the lung cancer group was higher than that in the tuberculosis group(P<0.05).The levels of serum NSE,CA125,CEA,and CYFRA21-1 in the lung cancer group were higher than those in the tuberculosis group(P<0.05).The sensitivity of the combined identifica-tion of MSCT and tumor markers was higher than that of single identification(P<0.05).Conclusion Combination of MSCT with serum NSE,CA125,CEA,and CYFRA21-1 has a higher diagnostic efficacy for thin-walled cystic lung cancer and thin-walled cavitary pulmonary tuberculosis.