Functional reorganization of auditory cortex and attention network in Presbycusis

WANG Jing; LIU Yuxi; MA Wen; GAO Fei; ZHAO Bin

doi:10.20258/j.cnki.1006-9011.2025.03.006

Abstract：Objective To discuss the changes in functional connectivity within the attention network,the alterations in func-tional connectivity between the attention network and the auditory cortex,as well as the relationship between these changes in functional connectivity regions and cognitive function in patients with presbycusis.Method 57 healthy controls and 60 presby-cusis patients were included in the study,and magnetic resonance imaging instruments were used for 3DTI and rsfMRI data ac-quisition.An attention network was constructed and bilateral Heschl's gyrus was selected as the region of interests in the auditory cortex.Finally,the cognitive function of all participants was evaluated.Result Patients with presbycusis exhibited decreased functional connectivity within the attention network and alterations in functional connectivity between the attention network and the auditory cortex.Meanwhile,altered functional connectivity within the attentional network was associated with cognitive func-tion among all participants.Conclusion The functional connectivity patterns within the attention network may be impaired in patients with presbycusis,the functional connection between attention network and auditory cortex has compensatory and decom-pensated relationship.These findings provide new insights into the cognitive compensation and resource reallocation mechanisms of presbycusis.