Prognostic value of serum circulating miR-210-3p and echocardiographic indicators in patients with acute heart failure

LI Jun; YU Lili; LI Fang; JIANG Qiyong; TANG Xijun; DENG Wei

doi:10.20258/j.cnki.1006-9011.2025.02.014

Abstract：Objective To analyze the expression level of serum miR-210-3p in patients with acute heart failure and the clini-cal value of echocardiographic indexes on its prognosis and to provide relevant reference for the diagnosis and rehabilitation of pa-tients with this disease.Methods The clinical data of 93 patients with acute heart failure admitted to our hospital were analyzed.According to the follow-up results,the patients were divided into two groups:the group with adverse cardiovascular events(23 cases)and the group without adverse cardiovascular events(70 cases).To analyze Then,we analyzed the expression level of miR-210-3p and echocardiographic indexes when patients were admitted to hospital,as well as analyzed the clinical value of the above indexes on the prognosis of patients.Results There were statistically significant differences(P<0.05)in the parameters of LVDd,LVDs,LAD,diastolic parameters,valve parameters,pulmonary artery pressure parameters,and total EMPS score detected by echocardiography between patients with and without cardiovascular adverse events.The relative expression level of miR-210-3p in patients with adverse cardiovascular events was significantly lower than that in patients without events(P<0.05).ROC curve analysis showed that the predicted AUC of miR-210-3p and echocardiography was 0.881 and 0.989 respectively.The diagnostic sensitivity was 87.0%and 99.2%and the specificity was 81.4%and 92.9%,respectively.Conclusion miR-210-3p and echocardiography have high clinical value in predicting the prognosis of patients with acute heart failure.