Risk assessment of pain associated with CT-guided lung microwave ablation

WANG Lina; LIU Jian; SHI Honglu; HAN Xujian; DOU Weitao; WANG Xueliang

doi:10.20258/j.cnki.1006-9011.2025.02.013

Abstract：Objective To evaluate the effects of intraoperative pain in percutaneous microwave ablation and to explore the risk factors moderate to severe pain associated with ablation.Methods Consecutive patients with lung tumors or nodules un-derwent CT-guided percutaneous microwave ablation were divided into moderate or severe pain(MSP,n=93)and mild or no pain(MNP,n=85)groups.We compared the differences in clinical data,lung lesion characteristics,ablation treatment param-eters between MSP and MNP group,and evaluated associations between above factors and moderate or severe pain caused by lung ablation.Result Compared with MNP group,there were lower depth of lesion[(10.1±5.2)mm vs(19.4±6.2)mm;P=0.009]and puncture[(29.5±6.7)mm vs(40.3±7.3)mm;P=0.012],longer total ablation time[(7.3±2.7)min vs(5.1±2.6)min;P=0.031],higher pleural involvement(35.5%vs 20.0%;P=0.015)and using multi-antennas(20.4%vs 8.2%;P=0.003)in MSP group.Logistic regression analysis showed that lesion depth[OR 0.69(95%CI:0.53-1.57);P=0.011],puncture depth[OR 0.63(95%CI:0.34-2.21);P=0.016],and using multi-antennas[OR 4.14(95%CI:1.12-10.33);P=0.023]were significantly correlated with moderate to severe pain associated with ablation.Conclusion Lesion close to pleura,low depth of puncture and using multi-antennas increase the risk of ablative pain,which reduces the local efficacy of lung ablation therapy.