The values of quantitative DCE-MRI combined with IVIM and DKI in the diagnosis of triple negative breast cancer

JIN Yan; WANG Yanhui; ZHAO Qing; LI Caixia; ZHAO Fuxiang; WANG Weiwei

Abstract：Objective To explore the diagnostic value of multimodal magnetic resonance imaging(IVIM+DKI+DCE-MRI model)for the diagnosis of triple negative breast cancer.Methods A total of 162 cases of breast cancer confirmed by pathology were collected,including 46 cases in the triple negative group and 116 cases in the non-triple negative group.IVIM,DKI and DCE-MRI scanning were performed in all patients.The clinicopathological characteristics and conventional MRI features and the quantitative parameters of IVIM,DKI,and DCE-MRI models were analyzed.Results Irregular lesions in the triple negative group were less common than those in the non-triple negative group(P=0.027).The triple negative group had higher proportion of patients with heterogeneous enhancement and rim enhancement(P=0.049).The D,f and MD,Kep values of the triple negative group were higher than those of the non-triple negative group(P<0.05).The MK and Ve values of the triple negative group were lower than those of the non-triple negative group(P=0.007;P<0.001).The AUC of Ve value was 0.820,which was higher than the other quantitative parameters(Z=2.336～3.706,P=0.002～0.020).The AUC of the DCE-MRI model was 0.851,which was greater than that of the IVIM(AUC=0.732)and DKI model(AUC=0.685),and the difference was statistically significant(Z=2.408,P=0.016;Z=3.081,P=0.002).The AUC of the combining IVIM,DKI and DCE-MRI models was 0.900,the diagnostic performance was higher than the single model(Z=2.294～5.330,P<0.05).Conclusion Multiparametric diffusion-weighted im-aging(IVIM+DKI+DCE-MRI)can be used for the diagnosis of triple negative breast cancer,and the DCE-MRI model has the highest diagnostic efficacy.The combination of the three methods is better than a single model.