Study on cortical metabolites changes over the course of migraine attack based on MRS
CHEN Yufan
XU Changyuan
ZHAO Yang
ZHUO Mengyuan
WANG Guangbin
Abstract：Objective To investigate the alteration of GABA-Glu in migraine and its role in the onset of attacks using MRS technology.Methods This study enrolled 19 migraine patients and 23 sex-and age-matched normal controls and obtained the anterior and posterior cingulate gyrus metabolite concentrations using MRS.We compared the differences in neurometabolite lev-els between the patient group and the normal control group,and then,analyzed the alterations in the neurometabolite levels dur-ing the ictal period compared with the interictal period in the patient group.Results 1)Compared with the normal control group,GABA levels in the anterior and posterior cingulate gyrus were elevated during migraine attacks,and there was a ten-dency for GABA levels in the anterior cingulate gyrus to increase during the interictal period,but there was no statistical signifi-cance(P>0.05);2)In the dynamic comparisons,the GABA levels in the anterior cingulate gyrus were increased in the migraine ictal period compared with the interictal period.Conclusion Increased GABA concentrations in the brain of migraine patients are associated with headache attacks,which may be related to the maintenance of excitatory-inhibitory homeostasis through GABA-driven inhibitory regulation of migraine attacks.
Keywords：MigraineMagnetic resonance spectroscopy imagingGamma-aminobutyric acidGlutamate
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 6-9 )