The value of energy spectrum CT combined with MRI-DWI in differentiating pulmonary inflammatory nodules from lung cancer

JIA Yanrong; ZHANG Fengxiang; ZHANG Fang; XU Yandong; QI Lixia; DU Hai

Abstract：Objective To investigate the value of energy spectrum CT combined with MRI-DWI in differentiating pulmonary inflammatory nodules from lung cancer.Methods Twenty five patients with pulmonary inflammatory nodules and 25 patients with lung cancer confirmed by pathology or follow-up were collected.All patients were scanned by gemenergy spectrum CT(GSI)and diffusion weighted MRI imaging(DWI).Statistical analysis was used to compare the differences of energy spectrum param-eters and ADC values between the two groups,and ROC curve was employed to analyze the diagnostic efficacy of each index.P＜0.05 was considered statistically significant.Results There were significant differences in Eff-Z,CT value of plain scan,CT value of arterial phase,CT value of venous phase,NIC of arterial phase,NIC of venous phase,dIC of venous phase,dCT of arte-rial phase and dCT of venous phase between the two groups(P<0.05).There were no significant differences in IC of arterial phase,IC of venous phase,dIC of arterial phase,λ40～90 of arterial phase and λ40～90 of venous phase between the two groups(P＞0.05).The difference of ADC values between the two groups was statistically significant(P<0.05).ADC values of lung cancer group were lower than those of pulmonary inflammatory nodules group under different b values.With the increase of b value,ADC value in lung cancer group decreased significantly.The diagnostic value of venous phase dCT was the highest among energy spectrum parameters,with AUC of 0.848(0.718～0.934),sensitivity of 80%,and specificity of 92%.The diagnostic value of b value 1000 in DWI scan was the highest,with AUC of 0.934(0.826～0.985),sensitivity of 96%,and specificity of 92%.The combination of the two methods had the best diagnostic efficacy.Conclusion Energy spectrum CT and MRI-DWI have impor-tant value in the differential diagnosis of pulmonary inflammatory nodules and lung cancer.The combination of the two methods can improve the differential diagnosis efficiency.