Construction of a nomogram model of hemorrhage transformation after AIS thrombolysis based on CT perfusion imag-ing parameters

WU Jing; XU Peng

Abstract：Objective Based on the parameters of CT perfusion imaging,a nomogram model of hemorrhage transformation af-ter thrombolysis in acute ischemic stroke(AIS)was constructed.Methods 160 patients with AIS who underwent thrombolytic therapy in our hospital were selected as the study objects,and all patients underwent skull CT perfusion examination.Lasso analysis was used to screen the predictive factors of hemorrhage transformation after AIS thrombolytic therapy,Logistic regres-sion was used to screen the risk factors of hemorrhage transformation after AIS thrombolytic therapy,and R software was used to build the column graph model of hemorrhage transformation after AIS thrombolytic therapy.Results Logistic regression analy-sis showed that large-scale infarction,atrial fibrillation,time from onset to thrombolysis＞3h,NIHSS score at admission,rCBF,and rCBV were risk factors for hemorrhage transformation after AIS thrombolysis(P＜0.05).The C-index of the nomogram model of hemorrhage transformation after AIS thrombolysis was 0.942(95%CI 0.903～0.981).The predicted value of the correction curve was basically consistent with the actual value.The area under ROC curve of the model was 0.929(95%CI 0.888～0.970).When the decision curve showed a threshold probability of 1%-84%,the net benefit value predicted by the nomogram was higher after AIS thrombolysis.Conclusion The accuracy and clinical application value of the nomogram model of hemorrhage transfor-mation after AIS thrombolysis are high.