Analyis of the application of NODDI in the volume of presumed vascular white matterhyperintensity

WANG Ben; GAO Deyu; WANG Yu

Abstract：Objective To observe the manifestations of presumed vascular white matter hyperintensity(WMH)in different volumes by neurite orientation dispersion and density imaging(NODDI)and to explore the application value of this technique.Methods The imaging data of 106 patients with putative vascular WMH were selected.The differences and correlations be-tween NODDI and DTI parameters in NAWM and WMH were compared.The differences of NAWM and WMH parameters be-tween different WMH volume groups were compared.Partial correlation analysis was used to analyze the correlation between NODDI,DTI parameters and WMH volume.Multiple linear regression was used to analyze the related factors of WMH volume en-largement.Results 1)The FA,NDI and ODI values of WMH were significantly lower than those of NAWM,and the MD and Viso values were significantly higher than those of NAWM(P＜0.05);2)There were no significant differences in FA and ODI val-ues of WMH and Viso and MD values of NAWM among the four groups(P＞0.05).MD,NDI and Viso values of WMH and FA,NDI and ODI values of NAWM were significantly different among the four groups(P<0.05);3)The FA and MD of WMH were significantly correlated with ODI and Viso of WMH(P<0.001),and the FA and MD of NAWM were significantly correlated with parameters of NODDI(P<0.001);4)The MD,NDI,ODI,Viso of WMH,FA,NDI,ODI of NAWM were significantly correlated with the volume of WMH(P<0.05);and 5)Linear regression analysis showed that WMH-Viso,WMH-NDI,and NAWM-ODI were independently correlated with the volume of WMH(P<0.05).Conclusion NODDI parameters are more sensitive to WMH than other DTI parameters such as FA and MD,which can more specifically reflect the changes of normal white matter.