Study of multiple resting state fMRI indicators in the brain functional network of patients with MRI-negative temporal lobe epilepsy
YAN Lingling
Hanjiaerbieke·KUKUN
WANG Yunling
JIA Lin
Abstract：Objective To investigate the abnormal changes of brain functional network in patients with MRI-negative tempo-ral lobe epilepsy.Methods The resting-state fMRI data of MRIn-TLE patients,MTLE-HS patients and healthy volunteers(HC group)were collected.After preprocessing,the amplitude of low-frequency fluctuation(ALFF),fractional amplitude of low-frequency fluctuation(fALFF)and regional homogeneity(ReHo)of each group were calculated,and the rs-fMRI parameters of each group were statistically analyzed.Results Compared with the HC group,the MRIn-TLE group showed a diffuse distribu-tion of abnormal brain regions,mainly showing the increased ALFF values in the putamen,inferior frontal gyrus and paracentral lobules in the triangle,the increased fALFF values in the cingulate gyrus,supplementary motor area,postcentral gyrus and an-gular gyrus,and the increased ReHo values in the cortex around the calcarine cleft,inferior temporal gyrus and cuneus.The ALFF values of the dorsal-lateral superior frontal gyrus,middle frontal gyrus,precuneus and cerebellum,the fALFF values of the cerebellum,inferior temporal gyrus and middle temporal gyrus,and the ReHo values of the dorsal-lateral superior frontal gyrus and precuneus all decreased.Compared with the HC group,the MTLE-HS group showed the increased ALFF,fALFF and ReHo values in the precuneus,mainly in the parietal lobe.Conclusion The resting-state fMRI parameters of multiple brain regions in MRIn-TLE patients were different from those in the control group,and the brain regions with differences were more widely distrib-uted than those in MTLE-HS patients,mainly including temporal lobe,frontal lobe,occipital lobe and parietal lobe.
Keywords：Temporal lobe epilepsyResting-state functional magnetic resonance imagingAmplitude of low frequency fluc-tuationFractional amplitude of low-frequency fluctuationRegional homogeneity
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 6-10,33 )