Relationship between RT-3DE parameters and ejection fraction retention of soluble oncogenic inhibitor 2 levels and car-diac function grading in patients with heart failure

GUO Qianqian; LI Bin; WANG Yueli; YU Wei

Abstract：Objective To analyze the correlation between real-time three-dimensional echocardiography(RT-3DE)param-eters and serum soluble carcinogenic inhibitory factor 2(sST2)levels and cardiac function in patients with ejection fraction pre-serving heart failure(HFpEF).Methods Eighty patients with HFpEF were selected as HFpEF group and divided into the fol-lowing groups according to the New York Heart Association(NYHA):Grade Ⅱ(14 cases),grade Ⅲ(48 cases),grade Ⅳ(18 cases),meanwhile,another 100 healthy volunteers who underwent physical examination in our hospital during the same pe-riod were selected as the control group.Serum sST2 levels of all subjects were detected by enzyme-linked immunosorbent assay(ELISA).Routine echocardiography and RT-3DE examination were performed on all subjects.TmsvDif%,TmsvSD%,left ven-tricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV),and left ventricular end-diastolic volume(LVEDV)were recorded at left ventricular segments 6,12 and 16.The correlation between RT-3DE parameters and serum sST2 level and cardiac function was analyzed.Results The LVEF of HFpEF patients with different cardiac function grades was sig-nificantly lower than that of control group,and the higher the cardiac function grade,the lower the LVEF was(P<0.05).The LVEDV and LVESV of HFpEF patients with different cardiac function grades were significantly higher than those of control group,and the higher the cardiac function grade,the higher the LVEDV and LVESV were(P<0.05).Tmsv 6-SD%,Tmsv12-SD%,Tmsv16-SD%and Tmsv 6-Dif%,Tmsv 12-Dif%and Tmsv 16-Dif%in HFpEF patients with different cardiac function grades were significantly longer than those in control group(P<0.05).The higher the cardiac function grade,the longer the Tms-vSD%and TmsvDif%of left ventricular segment 6,12 and 16(P<0.05);The serum sST2 expression level of HFpEF patients with different NYHA grades was higher than that of control group(P<0.05),and the sST2 level of HFpEF patients with higher cardiac function grades was significantly increased(P<0.05).Correlation analysis results showed that RT-3DE-related param-eters,i.e.,LVEDV,LVESV,Tmsv6-SD%,Tmsv12-SD%,Tmsv16-SD%,Tmsv 6-Dif%,Tmsv 12-Dif%,Tmsv 16-%Dif with NYHA heart function classification were significant positive correlation(r=0.687,0.752,0.501,0.565,0.581,0.522,0.596,0.603,P<0.05);There was a negative correlation between LVEF and NYHA cardiac function grade(r=-0.731,P<0.05).LVEDV and LVESV were positively correlated with serum sST2 expression(r=0.335,0.356,P<0.05);LVEF was negatively cor-related with serum sST2 and cardiac function grade(r=-0.313,P<0.05).Conclusion RT-3DE can effectively monitor the changes of left atrial volume function and left ventricular diastolic function in HFpEF patients.RT-3DE-related parameters are closely related to cardiac function grade,which is of great value for evaluating the degree of heart failure in patients.