The predictive value of FVH-DWI mismatch combined with serum IL-6 and miR-155 in patients with progressive cere-bral infarction

ZHAO Di; ZHANG Xiaolin; PAN Yan; SONG Yan

Abstract：Objective To explore the predictive value of fluid attenuated inversion recovery(FLAIR)sequence vascular high signal(FVH)-diffusion-weighted imaging(DWI)mismatch combined with serum interleukin(IL)-6 and micRNA-155(miR-155)in progressive cerebral infarction(PCI).Methods A total of 105 patients with cerebral infarction admitted to our hospital were selected as the study objects,among whom 35 patients had PCI(PCI group)and 70 patients had non-PCI(NPCI group).The expression levels of serum IL-6 and miR-155 were measured by enzyme-linked immunosorbent assay and real-time fluorescence quantitative polymerase chain reaction in all patients on the 1st day after admission,and relevant MRI examinations were performed to evaluate the mismatch of FVH-DWI.The predictive value of these indicators to PCI was analyzed by receiver operating characteristic(ROC)curve.Results The proportion of FVH-DWI mismatch in PCI group was significantly lower than that in NPCI group(25.71%vs 58.57%)(P<0.05).Serum IL-6 level[(121.77±30.34)vs(81.27±15.09)ng/L]and miR-155 expression level[(2.07±0.56)vs(1.51±0.56)]in PCI group were significantly higher than those in NPCI group(P<0.05).FVH-DWI mismatch was negatively correlated with NIHSS score(P<0.05),and serum IL-6 and miR-155 expression lev-els were positively correlated with NIHSS score(P<0.05).The area under the curve of FVH-DWI mismatch combined with serum IL-6 and miR-155 in the prediction of PCI was 0.919,and the sensitivity and specificity were 74.29%and 97.14%.Conclusions FVH-DWI mismatch combined with serum IL-6 and miR-155 detection has high predictive value for PCI.