Diagnostic value of deep medullary venous score combined with magnetic resonance(MRI)burden score on vascular cognitive impairment in elderly patients with cerebral small vessel disease

WU Jin; TAN Qin; LIU Fen; DENG ShiJie

Abstract：Objective To investigate the diagnostic value of deep medullary venous score combined with magnetic resonance imaging(MRI)burden score for vascular cognitive impairment(VIC)in elderly patients with cerebral small vessel disease(CSVD).Methods 188 elderly patients with CSVD were selected and divided into a VIC group of 123 cases and a non-VIC group of 65 cases based on whether they were complicated with VIC.According to the Montreal Cognitive Assessment(MoCA)score,the VIC group was divided into a non-severe VIC group of 91 cases and a severe VIC group of 32 cases.All patients under-went cranial MRI examination,and the deep medullary vein score and magnetic resonance burden score were calculated.Multi-variate logistic regression was used to analyze the influencing factors of VIC,and receiver operating characteristic curve(ROC)was used to analyze the diagnostic efficacy of deep medullary vein score and magnetic resonance burden score for VIC.Results There were significant differences in age,smoking history,past stroke history,hypertension,diabetes,hyperlipidemia,fasting blood glucose,total cholesterol,deep medullary vein score and magnetic resonance burden score between the VIC group and the non-VIC group(P<0.05).Hypertension,diabetes,hyperlipidemia,deep medullary vein score and magnetic resonance burden score were independent risk factors for VIC(P<0.05).The deep medullary vein score and magnetic resonance burden score were positively correlated with MMSE score and MoCA score(P<0.05).The deep medullary vein score and magnetic resonance bur-den score in the severe VIC group were higher than those in the non-severe VIC group(P<0.05).The sensitivity,specificity,and AUC of the combination of deep medullary vein score and magnetic resonance burden score in diagnosing VIC were 88.76%,51.32%,and 0.917,respectively.Conclusion The deep medullary vein score and the magnetic resonance burden score have correlation with cognitive function of the elderly CSVD patients,and the combination of these two scores has a suggestive role in the diagnosis of VIC.