Study on the correlation between non-alcoholic fatty liver and coronary CT angiography-derived fractional flow reserve
LI Sha
ZHANG Shuai
MA Wenshan
XU Tianqi
CHANG Kai
SHI Rongchao
WANG Ximing
Abstract：Objective To explore the correlation between non-alcoholic fatty liver disease(NAFLD)and coronary artery he-modynamic abnormalities.Methods 340 patients who underwent CCTA examination from January 2016 to December 2018 were retrospectively enrolled.Patients were divided into NAFLD group(126)and non-NAFLD group(214)based on whether the liver/spleen CT value ratio was≤1.0.The differences were compared between the two groups in general information,plaque properties,high-risk plaques,and coronary CT angiography-derived fractional flow reserve(CT-FFR).The correlation between NAFLD and CT-FFR≤0.8 was analyzed using binary logistic regression.Results The study included 126 participants in the NAFLD group and 214 participants in the non-NAFLD group.The two groups were statistically different in terms of diabetes mel-litus,hyperlipidemia,family history of coronary artery disease,aspartate aminotransferase(AST),alanine aminotransferase(ALT),glutamyl transpeptidase(GGT),and uric acid levels(all P<0.05).Non-calcified plaques,high-risk plaques,and CT-FFR≤0.8 were significantly higher than those of non-NAFLD patients(all P<0.05).The results of multivariate correlation analysis showed that after adjusting for traditional cardiovascular risk factors,calcified plaques,partially calcified plaques,high-risk plaques,and obstructive plaques,NAFLD remained an independent predictor of CT-FFR≤0.8(OR:2.283;95%CI:1.156-4.507;P=0.017).Conclusion NAFLD is associated with abnormal coronary hemodynamics based on CCTA detection,independent of traditional cardiovascular risk factors and CCTA anatomic parameters.
Keywords：Non-alcoholic fatty liver diseaseCoronary CT angiography-derived fractional flow reserveCoronary artery dis-easeTomographyX-ray computed
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 31-35 )