Quantitative susceptibility mapping(QSM)study of iron metabolism abnormalities in deep brain nuclei of migraine patients and their relationship to cognitive changes
XU Longji
YANG Jing
REN Fuxin
LI Xi
WANG Jing
LIU Yuxi
ZHANG Wenjing
GAO Fei
ZHAO Bin
Abstract：Objective To investigate the changes in iron metabolism in deep brain nuclei of migraine patients using quantita-tive magnetic susceptibility mapping(QSM)and their relationship with cognitive and emotional changes.Methods This study included 38 migraine patients(MIG)and 41 healthy controls(HCs).Using magnetic resonance sequences QSM,we investi-gated the changes in iron deposition in the nucleus accumbens(NAC),cerebellar dentate nucleus(DN),extended amygdala(EXA),substantia nigra pars compacta(SNc),red nucleus(RN),substantia nigra reticular region(SNr),peribrachial pig-ment nuclei(PBP),hypothalamus(HTH),and subthalamic nucleus(STH),as well as observed their correlation with cogni-tive,emotional,and migraine characteristics.Results The MIG group exhibited various cognitive impairments.The QSM val-ues of NAC(P=0.032),EXA(P=0.035),SNc(P=0.019),RN(P=0.014),and SNr(P=0.010)in the MIG group were higher than those in the HC group.In addition,the QSM values of NAC(r=0.439,P=0.008)and EXA(r=0.512,P=0.002)were posi-tively correlated with the TMT-A score.The QSM value of RN(r=0.448,P<0.007)was positively correlated with the MSQ score.The QSM value of SNr(r=0.448,P<0.007)was positively correlated with PHQ9 score.Conclusion This study provides a new perspective for analyzing cognitive and emotional changes in migraine patients.
Keywords：MigraineQuantitative magnetic susceptibility mappingIron depositionCognitiveAnxietyMagnetic reso-nance imaging
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )