Study on the correlation and diagnostic value of ultrasound multimodal imaging parameters with CA153 and CA125 ex-pression in breast cancer

LIU Hui; GAO Manli; XIE Qingqing; ZHANG Nan; BAO Di; LIU Li

Abstract：Objective To investigate the correlation and diagnostic value of ultrasound multimodal imaging parameters with CA153 and CA125 expression in breast cancer.Methods A total of 260 female breast nodule patients admitted to our depart-ment,all of whom were single nodules,were divided into a study group and a control group based on postoperative pathological findings,of which 109 patients with breast cancer were in the study group and 151 patients with benign breast tumour were in the control group.Then,we analysed the value of applying ultrasound multimodal imaging parameters in conjunction with serum tu-mour markers for the differential diagnosis of benign and malignant breast tumours.Results The maximum blood flow,resis-tance index and pulsatility index of the study group were higher than those of the control group(P<0.05);The peak intensity,slope of ascending branch and gradient of the study group were higher than those of the control group,while,the peak time was shorter than those of the control group(P<0.05);The levels of CA153 and CA125 of the study group were higher than those of the control group(P<0.05);All ultrasound indicators were positively correlated to serum CA153 and CA125 of the breast cancer patients(P<0.05),except for the negative correlation of peak time with both CA153 and CA125.Multivariate Logistic regression analysis showed that maximum blood flow velocity,blood flow resistance,pulse index,peak intensity,ascending branch slope,peak time,gradient,CA153 and CA125 were independent risk factors for malignant breast nodular lesions(P<0.05).The re-sults of ROC curve showed that the AUCs of ultrasound blood flow signal,ultrasonography,CA153,CA125 and combined appli-cation were 0.812,0.890,0.712,0.634,and 0.953,respectively.The diagnostic efficacy of combined application was higher than that of ultrasound blood flow signal,contrast-enhanced ultrasound,CA153,and CA125(P<0.05).Conclusion Ultra-sound multimodal imaging parameters combined with serum tumour markers have high differential diagnostic power for benign and malignant breast tumours.